The innovation of EPSOLAY cream

What patients will want to know about EPSOLAY cream

Explore instructions for use and more.

Explore EPSOLAY cream
EPSOLAY packaging

What makes EPSOLAY cream different

See how encapsulated benzoyl peroxide (E-BPO) can provide benefits for rosacea patients.1

Discover E-BPO

Results from real patients

Patients noticed clearer skin in as little as two weeks in a clinical study looking primarily at BPO efficacy for inflammatory rosacea lesions over 12 weeks.2

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Man with rosacea looking into the camera

Designed with sensitive rosacea skin in mind1

See the studies on tolerability.

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Your patients may pay as little as $0*

The Mayne Pharma Patient Savings Card can act like an EPSOLAY savings coupon to help reduce the cost of EPSOLAY cream for insured or uninsured patients, if approved.

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Woman with rosacea looking up to the left and smiling

References:

  1. EPSOLAY (benzoyl peroxide) cream, 5% [prescribing information]. Raleigh (NC): Mayne Pharma; revised 2025 Feb.
  2. Bhatia N, Werschler WP, Baldwin H, Sugarman J, Green LJ, Levy-Hacham O, et al. Efficacy and safety of microencapsulated benzoyl peroxide cream, 5%, in rosacea: results from two phase III, randomized, vehicle-controlled trials. J Clin Aesthet Dermatol. 2023;16(8):34-40.

*Certain limitations may apply.

The Patient Savings Card Program (“Program”) is brought to you by Mayne Pharma. The Program is only available for commercially unrestricted or commercially restricted/cash-paying patients at participating pharmacies. Patients who are enrolled in state or federally government-run or government-sponsored healthcare plan with a pharmacy benefit are not eligible to use the Mayne Pharma Patient Savings Card (“Card”). Any claim under the Program must be submitted by participating pharmacies to one of the Administrators of the Program.

The Program is subject to applicable state and federal law and is void where prohibited by law, rule or regulation. In the event a lower cost generic drug that the FDA has designated as a therapeutic equivalent product is available for one of the products covered by the Program, or if the active ingredient of a product is available at a lower cost without a prescription, this offer will become void in California and Massachusetts with respect to the product.

Important Safety Information

Indications and usage: EPSOLAY® (benzoyl peroxide) cream, 5% is indicated for the treatment of inflammatory lesions of rosacea in adults.

Contraindications: A history of hypersensitivity reactions to benzoyl peroxide or any component of the formulation in EPSOLAY.

Warnings and precautions: 

  • Hypersensitivity: Severe hypersensitivity reactions, including anaphylaxis and angioedema, have been reported with the use of benzoyl peroxide products.
  • Skin irritation/contact dermatitis: Erythema, scaling, dryness, stinging/burning, irritation and allergic contact dermatitis may occur with the use of EPSOLAY and may necessitate discontinuation.
  • Photosensitivity: Avoid or minimize exposure to natural or artificial sunlight and use sun protection measures.

Adverse reactions: Most common adverse reactions (incidence ≥1%) are application site reactions: pain erythema, pruritus, and edema.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.